Patient case report on the use of the NanoTherm® therapy for the treatment of relapsed glioblastoma after resection
- Initial diagnosis of a glioblastoma on January 5, 2007, WHO Grade IV, temporal right
- Total resection on January 8, 2007 followed by Temozolomide treatment and radiotherapy from January 30 – March 15, 2007
- Diagnosis of a relapse on May 18, 2007
On January 5, 2007 a histologically confirmed glioblastoma, WHO Grade IV, temporo-occipital right, was diagnosed in the 39-year-old patient. On January 8, 2007, the tumor was completely resected. Treatment with Temozolomide was started on January 17, 2007, with a concomitant radiotherapy with a total of 59.4 Gy (1.8 Gy/d) from January 30 – March 15, 2007. From April 25 – May 16, 2007, the patient was treated exclusively with Temozolomide.
Decision for NanoTherm® Therapy
On May 18, 2007 a relapse with a tumor volume of 2.5 ml was diagnosed by CT scan on the temporo-occipital right within the former tumor resection area. The treating neurosurgeons did not recommend resection of the relapse because of a possible hemiparesis, and instead decided to treat with NanoTherm® therapy.
- Intervention with 5 punctures on July 11, 2007
- Treatment of patient with alternating magnetic field in the NanoActivator® (July 18 - August 3, 2007: twice a week for 1 hour over a period of 3 weeks, in total 6 sessions)
- Simultaneous radiotherapy with a total does of 29.9 Gy (13 x 2.3 Gy)
The only reported side effect from the NanoTherm® therapy was sweating. No other side effects or complaints were reported by the patient.
- CT follow-up scans performed at 2, 4, 7, 10, 14, 18, 22 and 24 months after completion of NanoTherm® Therapy showed no indication of a tumor relapse
- Last contact: June 2011, the patient is alive (47 months)
NanoTherm®, NanoPlan®, and NanoActivator® are components of the therapy and have received EU-wide certification (CE mark) as medical devices for the treatment of brain tumors. NanoTherm® therapy is currently available to national and foreign patients in dedicated hospitals in Germany.