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Patient case report on the use of the NanoTherm® therapy for the treatment of recurrent glioblastoma

Course of disease in a 24-year-old patient


On July 21, 2006 a histologically verified left glioblastoma, WHO Grade IV, was diagnosed in a 24-year-old patient. On July 27, 2006 the tumor measuring 5.5 cm x 5 cm was totally resected. From August 30 – October 1, 2006 radiotherapy (2 Gy/d) was performed with a total dose of 50 Gy. However, on November 16, 2006, a relapse with a tumor volume of 5.3 ml was diagnosed via MRI.

Decision for NanoTherm® Therapy

After postoperative FET-PET and CT on January 24, 2007, the decision was made to treat with NanoTherm® therapy in combination with simultaneous radiotherapy. Prior to the instillation of the nanoparticles on January 30, 2007 an MRI was conducted in order to localize the tumor.


Side effects

During this therapy, the patient appeared twice to feel disoriented for a few minutes. Apart from this, the patient did not complain of any further side effects.


NanoTherm®, NanoPlan®, and NanoActivator® are components of the therapy and have received EU-wide certification (CE mark) as medical devices for the treatment of brain tumors. NanoTherm® therapy is currently available to national and foreign patients in dedicated hospitals in Germany.



For more information, please contact our Patient Services under T: +49 30 - 30 83 80 - 73 (free call within Germany: 0800 - 66 46 46 1) or ask your physician. You can also write us at